Which of the following is a sign of chronic kidney disease?

Decreased appetite is indeed a common sign of chronic kidney disease (CKD). As kidney function declines, the accumulation of waste products and toxins in the bloodstream can lead to a range of symptoms, including loss of appetite. This can manifest as a reluctance to eat or a sense of fullness even after consuming small meals. Malnutrition and weight loss are often associated issues in patients with CKD, partly driven by this decrease in appetite.

In contrast, increased energy, clear urine, and weight gain do not typically align with CKD symptoms. Increased energy is usually not a characteristic of this condition; patients often feel fatigued due to anemia and the metabolic effects of the disease. Clear urine can indicate good kidney function and hydration, but in CKD, urine may appear cloudy or contain abnormal substances. Weight gain may occur in certain situations, but CKD is more commonly associated with weight loss as a result of decreased appetite and nutrient absorption issues.